Eosinophilic gastrointestinal disorders (EGIDs) in children

Eosinophilic gastrointestinal disorders (EGIDs) in children

Digestive Disorder

Eosinophilic gastrointestinal disorders (EGIDs) are chronic digestive system disorders in which certain food proteins trigger an overproduction of eosinophils (white blood cells that help fight certain infections), in different areas of the digestive tract.

EGIDs typically fall into one of three types:

Eosinophilic esophagitis (EoE): EoE is the most common and difficult type of EGID to manage. It is characterized by inflammation of the esophagus due to abnormally high levels of eosinophils in that area of the GI tract. Symptoms can include abdominal pain, diarrhea, nausea, severe vomiting, difficulty swallowing, and, at times, obstruction.

Eosinophilic gastroenteritis: Associated with eosinophils and inflammation in the stomach and small intestine

Eosinophilic colitis: Associated with eosinophils and inflammation in the large intestine

Common symptoms of EGIDs

  • Vomiting or nausea
  • Abdominal or chest pain
  • Acid reflux that does not respond to usual therapy
  • Bloating
  • Blood in the stool
  • Diarrhea
  • Poor growth or weight gain
  • Difficulty swallowing
  • Gastroparesis
  • Malnutrition
  • Anemia


How to manage EGIDs

Your doctor may be able to identify specific food proteins that trigger the overproduction of eosinophils in your child. Your doctor may recommend an elimination diet where the offending proteins are not consumed. Often a stricter diet — an amino acid-based diet — is prescribed.
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